DIRECT INTERACTION NETWORK AND DIFFERENTIAL NETWORK INFERENCE FROM COMPOSITIONAL DATA VIA LASSO PENALIZED D-TRACE LOSS.

Direct interaction network and differential network inference from compositional data via lasso penalized D-trace loss.

The development of high-throughput sequencing technologies for 16S rRNA gene profiling provides higher quality compositional data for microbe communities.Inferring the direct interaction network under a specific condition and understanding how the network structure changes between two different environmental or genetic conditions are two important

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The change of gut microbiota in MDD patients under SSRIs treatment

Abstract The alterations in the gut microbiota have been reported to be correlated with the development of depression.The purpose of this study was Business Card Scanner to investigate the changes of intestinal microbiota in depressed patients after antidepressant treatment.We recruited 30 MDD patients (MDD group) and 30 healthy controls (control g

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A longitudinal field study of commercial honey bees shows that non-native probiotics do not rescue antibiotic treatment, and are generally not beneficial

Abstract Probiotics are widely used in agriculture including commercial beekeeping, but there is little evidence supporting their effectiveness.Antibiotic treatments can greatly distort the gut microbiome, reducing its protective abilities and facilitating the growth of antibiotic resistant pathogens.Commercial beekeepers regularly apply antibiotic

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Cytogenetic analysis on Turkonalassus quercanus Keskin, Nabozhenko et Alpagut-Keskin, 2017 (Coleoptera: Tenebrionidae: Helopini)

Cytogenetic features of the endemic Western Anatolian tenebrionid species Turkonalassus quercanus Keskin, Nabozhenko et Alpagut-Keskin, 2017 were Peppermint Tea analyzed using conventional and differential staining.Chromosome preparations were obtained from the gonads of both males and females.The karyotype of T.quercanus was found to be 2n = 20 (9

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The Role of S-Nitrosylation and S-Glutathionylation of Protein Disulphide Isomerase in Protein Misfolding and Neurodegeneration

Neurodegenerative diseases involve the progressive loss of neurons, and a pathological hallmark is the presence of abnormal inclusions containing misfolded proteins.Although the precise molecular mechanisms triggering neurodegeneration remain unclear, endoplasmic reticulum (ER) stress, elevated oxidative and nitrosative stress, and protein misfoldi

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